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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR3 S249C FGFR3 V555L||transitional cell carcinoma||predicted - resistant||Erdafitinib||Case Reports/Case Series||Actionable||In a clinical case study, FGFR3 V555L was identified in the post-progression circulating tumor DNA of a patient with urothelial cancer harboring FGFR3 S249C who previously responded to Balversa (erdafitinib) treatment (PMID: 37377403).||37377403|
|FGFR3 S249C FGFR3 V555L||transitional cell carcinoma||predicted - resistant||Pemigatinib||Case Reports/Case Series||Actionable||In a Phase II trial (FIGHT-201), FGFR3 V555L was identified in post-progression biopsy in a patient with urothelial carcinoma harboring FGFR3 S249C who previously achieved stable disease on Pemazyre (pemigatinib) treatment (PMID: 37956738; NCT02872714).||37956738|