Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
ID | DOID:2671 |
Name | transitional cell carcinoma |
Definition | A carcinoma that derives_from transitional epithelial cells. |
Source | DiseaseOntology.org |
Alt Ids | DOID:3995 |
Path | disease disease of cellular proliferation cancer cell type cancer carcinoma transitional cell carcinoma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
Unknown unknown | Ascrinvacumab | transitional cell carcinoma | not applicable | detail... |
FGFR3 dec exp FGFR3 wild-type HRAS G12V | AZ8010 | transitional cell carcinoma | decreased response | detail... |
FGFR3 dec exp FGFR3 wild-type HRAS G12V | AZD4547 | transitional cell carcinoma | resistant | detail... |
FGFR3 S249C FGFR3 over exp | PD173074 | transitional cell carcinoma | sensitive | detail... |
FGFR3 over exp | AZD4547 | transitional cell carcinoma | sensitive | detail... |
FGFR3 over exp | AZ8010 | transitional cell carcinoma | sensitive | detail... |
FGFR3 dec exp FGFR3 wild-type HRAS G12V | PD173074 | transitional cell carcinoma | resistant | detail... |
FGFR3 - TACC3 | Erdafitinib | transitional cell carcinoma | sensitive | detail... |
FGFR2 - BICC1 FGFR2 - CASP7 | Erdafitinib | transitional cell carcinoma | predicted - sensitive | detail... |
Unknown unknown | Docetaxel + Ramucirumab | transitional cell carcinoma | not applicable | detail... |
Unknown unknown | Docetaxel + Icrucumab | transitional cell carcinoma | no benefit | detail... |
Unknown unknown | Paclitaxel + Pazopanib | transitional cell carcinoma | not applicable | detail... |
Unknown unknown | Atezolizumab | transitional cell carcinoma | not applicable | detail... |
FGFR3 - TACC3 | Alpelisib + Infigratinib | transitional cell carcinoma | predicted - sensitive | detail... |
NRAS mutant | Trametinib | transitional cell carcinoma | decreased response | detail... |
HRAS mutant | Trametinib | transitional cell carcinoma | resistant | detail... |
ERBB2 positive | lapuleucel-T | transitional cell carcinoma | no benefit | detail... |
Unknown unknown | Cabozantinib | transitional cell carcinoma | not applicable | detail... |
FGFR3 mutant | Infigratinib | transitional cell carcinoma | sensitive | detail... |
FGFR3 fusion | Infigratinib | transitional cell carcinoma | sensitive | detail... |
Unknown unknown | Domatinostat | transitional cell carcinoma | not applicable | detail... |
Unknown unknown | Nivolumab | transitional cell carcinoma | not applicable | detail... |
Unknown unknown | Everolimus | transitional cell carcinoma | not applicable | detail... |
Unknown unknown | Durvalumab | transitional cell carcinoma | not applicable | detail... |
Unknown unknown | Avelumab | transitional cell carcinoma | not applicable | detail... |
Unknown unknown | Pembrolizumab | transitional cell carcinoma | not applicable | detail... |
FGFR3 - TACC3 | AZD4547 + Buparlisib | transitional cell carcinoma | sensitive | detail... |
FGFR1 amp | AZD4547 + Buparlisib | transitional cell carcinoma | sensitive | detail... |
FGFR3 - TACC3 | AZD4547 | transitional cell carcinoma | predicted - sensitive | detail... |
FGFR3 mutant | Docetaxel + Vofatamab | transitional cell carcinoma | predicted - sensitive | detail... |
FGFR3 fusion | Docetaxel + Vofatamab | transitional cell carcinoma | predicted - sensitive | detail... |
FGFR1 mutant | Erdafitinib | transitional cell carcinoma | predicted - sensitive | detail... |
FGFR2 mutant | Erdafitinib | transitional cell carcinoma | sensitive | detail... |
FGFR3 mutant | Erdafitinib | transitional cell carcinoma | sensitive | detail... |
FGFR3 V555L | Infigratinib | transitional cell carcinoma | resistant | detail... |
FGFR3 V555M FGFR3 L608V | Infigratinib | transitional cell carcinoma | resistant | detail... |
FGFR3 V555M | Infigratinib | transitional cell carcinoma | resistant | detail... |
FGFR3 R248C | Erdafitinib | transitional cell carcinoma | sensitive | detail... |
FGFR3 S249C | Erdafitinib | transitional cell carcinoma | sensitive | detail... |
FGFR3 G370C | Erdafitinib | transitional cell carcinoma | sensitive | detail... |
FGFR3 Y373C | Erdafitinib | transitional cell carcinoma | sensitive | detail... |
FGFR3 - TACC3 | Debio 1347 | transitional cell carcinoma | predicted - sensitive | detail... |
Unknown unknown | Sabatolimab + Spartalizumab | transitional cell carcinoma | not applicable | detail... |
Unknown unknown | Toripalimab | transitional cell carcinoma | not applicable | detail... |
FGFR3 mutant | Nivolumab | transitional cell carcinoma | no benefit | detail... |
FGFR3 mutant | Atezolizumab | transitional cell carcinoma | no benefit | detail... |
FGFR3 fusion | Erdafitinib | transitional cell carcinoma | predicted - sensitive | detail... |
FGFR2 fusion | Erdafitinib | transitional cell carcinoma | predicted - sensitive | detail... |
Unknown unknown | Enfortumab vedotin-ejfv | transitional cell carcinoma | not applicable | detail... |
Unknown unknown | Lenvatinib + Pembrolizumab | transitional cell carcinoma | not applicable | detail... |
HRAS act mut | Tipifarnib | transitional cell carcinoma | predicted - sensitive | detail... |
HRAS mutant | Tipifarnib | transitional cell carcinoma | predicted - sensitive | detail... |
ARID1A inact mut | unspecified immune checkpoint inhibitor | transitional cell carcinoma | not predictive | detail... |
SMARCB1 inact mut | unspecified immune checkpoint inhibitor | transitional cell carcinoma | not predictive | detail... |
Unknown unknown | Buparlisib | transitional cell carcinoma | not applicable | detail... |
PIK3CA H1047R | Buparlisib | transitional cell carcinoma | no benefit | detail... |
ERBB2 positive | Disitamab vedotin | transitional cell carcinoma | predicted - sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT00978250 | Phase II | 5-Fluoro-2-deoxycytidine + Tetrahydrouridine | A Multi-Histology Phase II Study of 5-Fluoro-2-Deoxycytidine With Tetrahydrouridine (FdCyd + THU) | Completed | USA | 0 |
NCT01004224 | Phase I | Infigratinib | A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies | Completed | USA | 13 |
NCT01920061 | Phase I | Dacomitinib + Gedatolisib Cisplatin + Gedatolisib Docetaxel + Gedatolisib | A Study Of PF-05212384 In Combination With Other Anti-Tumor Agents and in Combination With Cisplatin in Patients With Triple Negative Breast Cancer in an Expansion Arm (TNBC) | Completed | USA | CAN | 3 |
NCT02052778 | Phase Ib/II | Futibatinib | A Study of TAS-120 in Patients With Advanced Solid Tumors | Active, not recruiting | USA | 9 |
NCT02393248 | Phase Ib/II | Cisplatin + Gemcitabine + Pemigatinib Docetaxel + Pemigatinib Pemigatinib + Retifanlimab Pemigatinib + Trastuzumab Epacadostat + Pembrolizumab | Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101) | Active, not recruiting | USA | 1 |
NCT02501096 | Phase Ib/II | Pembrolizumab Lenvatinib | Phase 1b/2 Trial of Lenvatinib (E7080) Plus Pembrolizumab in Subjects With Selected Solid Tumors | Active, not recruiting | USA | 2 |
NCT02516241 | Phase III | Durvalumab + Tremelimumab Carboplatin + Cisplatin + Gemcitabine Durvalumab | Study of MEDI4736 With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer | Active, not recruiting | USA | CAN | 22 |
NCT02573259 | Phase I | PF-06801591 | A Dose Escalation Study Of PF-06801591 In Melanoma, Head And Neck Cancer (SCCHN), Ovarian, Sarcoma, Non-Small Cell Lung Cancer, Urothelial Carcinoma or Other Solid Tumors | Completed | USA | 6 |
NCT02599324 | Phase Ib/II | Cetuximab + Ibrutinib Ibrutinib + Paclitaxel Everolimus + Ibrutinib Docetaxel + Ibrutinib | A Study to Evaluate Ibrutinib Combination Therapy in Patients With Selected Gastrointestinal and Genitourinary Tumors | Active, not recruiting | USA | 3 |
NCT02603432 | Phase III | Avelumab | A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100) | Active, not recruiting | USA | CAN | 27 |
NCT02628535 | Phase I | MGD009 | Safety Study of MGD009 in B7-H3-expressing Tumors | Terminated | USA | CAN | 1 |
NCT02660034 | Phase I | Pamiparib + Tislelizumab | The Safety, Pharmacokinetics and Antitumor Activity of BGB-A317 in Combination With BGB-290 in Participants With Advanced Solid Tumors | Completed | USA | 5 |
NCT02717156 | Phase II | Pembrolizumab + sEphB4-HSA | Recombinant EphB4-HSA Fusion Protein and Pembrolizumab in Treating Patients With Metastatic or Recurrent Urothelial Cancer That Is Refractory to Certain Chemotherapy Drugs | Recruiting | USA | 0 |
NCT02795156 | Phase II | Cabozantinib Afatinib Regorafenib | Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations | Recruiting | USA | 0 |
NCT02807636 | Phase III | Atezolizumab + Carboplatin + Gemcitabine Carboplatin + Gemcitabine | The Effect of Atezolizumab in Combination With Gemcitabine/Carboplatin and Gemcitabine/Carboplatin Alone in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma Who Are Ineligible for Cisplatin-based Therapy | Active, not recruiting | USA | CAN | 33 |
NCT02812420 | Phase I | Durvalumab + Tremelimumab | Pre-Surgical Study Evaluating Anti-PD-L1 Antibody (Durvalumab) Plus Anti-CTLA-4 (Tremelimumab) in Patients With Muscle-Invasive, High-Risk Urothelial Carcinoma Who Are Ineligible for Cisplatin-based Neoadjuvant Chemotherapy | Active, not recruiting | USA | 0 |
NCT02834013 | Phase 0 | Ipilimumab + Nivolumab | Nivolumab and Ipilimumab in Treating Patients With Rare Tumors | Recruiting | USA | 0 |
NCT02872714 | Phase II | Pemigatinib | A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Urothelial Carcinoma - (FIGHT-201) | Active, not recruiting | USA | 10 |
NCT02880345 | Phase 0 | Pembrolizumab | RADVAX: A Trial of Combined Pembrolizumab and Hypofractionated Radiation in Patients With Advanced Urothelial Cancer Who Have Progressed on Anti-PD-1/PD-L1 Monotherapy | Withdrawn | USA | 0 |
NCT03018405 | Phase Ib/II | NKR-2 cells | A Dose Escalation Phase I Study to Assess the Safety and Clinical Activity of Multiple Cancer Indications (THINK) | Recruiting | USA | 1 |
NCT03029832 | Phase II | Atezolizumab Atezolizumab + MOXR0916 | A Study of MOXR0916 in Combination With Atezolizumab Versus Atezolizumab Alone in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma Who Are Ineligible for Cisplatin-Based Therapy | Terminated | USA | CAN | 3 |
NCT03036098 | Phase III | Cisplatin + Gemcitabine Ipilimumab + Nivolumab Carboplatin + Gemcitabine | Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care Chemotherapy in Treatment of Patients With Untreated Inoperable or Metastatic Urothelial Cancer | Recruiting | USA | CAN | 29 |
NCT03047213 | Phase II | Sapanisertib | Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations | Active, not recruiting | USA | 0 |
NCT03076372 | Phase I | MM-310 | A Study Evaluating MM-310 in Patients With Solid Tumors | Unknown status | USA | 0 |
NCT03091660 | Phase III | BCG Tokyo-172 Strain Solution BCG solution | Different Strains of BCG With or Without Vaccine in High Grade Non- Muscle Invasive Bladder Cancer | Active, not recruiting | USA | 0 |
NCT03115801 | Phase II | Atezolizumab Nivolumab | A Phase II Randomized Trial of Immunotherapy Plus Radiotherapy in Metastatic Genitourinary Cancers | Active, not recruiting | USA | 0 |
NCT03123055 | Phase I | Atezolizumab + Vofatamab | A Study of B-701 in Combination With Atezolizumab in Treatment of Locally Advanced or Metastatic Urothelial Cell Carcinoma (U22) | Terminated | USA | 16 |
NCT03138889 | Phase I | NKTR-214 + Pembrolizumab | A Study of a CD122-Biased Cytokine (NKTR-214) in Combination With Anti-PD-1 (Pembrolizumab) in Patients With Select Advanced or Metastatic Solid Tumors (PROPEL) | Recruiting | USA | 5 |
NCT03179943 | Phase II | Atezolizumab + Guadecitabine | Overcoming Chechkpoint Inhibitor Resistance With Epigenetic Therapy in Urothelial Cancer | Active, not recruiting | USA | 0 |
NCT03207867 | Phase II | PBF-509 + Spartalizumab | A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma | Recruiting | USA | 13 |
NCT03208712 | Phase I | Atezolizumab + Radium Ra 223 dichloride | Radium-223 and Atezolizumab in Patients With Urothelial Carcinoma With Bone Metastases Who Have Had Disease Progression After Platinum-Based Chemotherapy | Terminated | USA | 0 |
NCT03219333 | Phase II | Enfortumab vedotin-ejfv | A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer (EV-201) | Active, not recruiting | USA | 7 |
NCT03236935 | Phase I | L-NMMA + Pembrolizumab | Phase Ib of L-NMMA and Pembrolizumab | Recruiting | USA | 0 |
NCT03240016 | Phase II | Nab-paclitaxel + Pembrolizumab | Abraxane With Anti-PD1/PDL1 in Cisplatin-ineligible Patients With Advanced Urothelial Cancer | Recruiting | USA | 0 |
NCT03241173 | Phase Ib/II | INCAGN01949 + Ipilimumab INCAGN01949 + Nivolumab INCAGN01949 + Ipilimumab + Nivolumab | A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies | Completed | USA | 0 |
NCT03264066 | Phase II | Atezolizumab + Cabozantinib | A Study to Investigate the Efficacy and Safety of Cobimetinib Plus Atezolizumab in Participants With Solid Tumors | Completed | USA | 5 |
NCT03277352 | Phase Ib/II | Epacadostat + INCAGN01876 + Pembrolizumab | INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies | Completed | USA | 0 |
NCT03287050 | Phase I | Pembrolizumab | Anti-PD(L)1 and SBRT in the Treatment of Advanced, Platinum-Refractory Urothelial Carcinoma | Completed | USA | 0 |
NCT03288545 | Phase I | Atezolizumab + Enfortumab vedotin-ejfv + Pembrolizumab | A Safety Study of Enfortumab Vedotin Plus Immune Checkpoint Inhibitor Therapy for Patients With Urothelial Bladder Cancer (EV-103) | Recruiting | USA | CAN | 0 |
NCT03289962 | Phase I | RO7198457 Atezolizumab + RO7198457 | A Study of RO7198457 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors | Recruiting | USA | CAN | 6 |
NCT03311334 | Phase I | Atezolizumab + DSP-7888 DSP-7888 + Nivolumab | A Study of DSP-7888 Dosing Emulsion in Combination With Immune Checkpoint Inhibitors in Adult Subjects With Advanced Solid Tumors | Recruiting | USA | CAN | 0 |
NCT03317496 | Phase II | Avelumab + Cisplatin + Gemcitabine Avelumab + Carboplatin + Pemetrexed Disodium | Safety And Efficacy Study Of Avelumab Plus Chemotherapy With Or Without Other Anti-Cancer Immunotherapy Agents In Patients With Advanced Malignancies | Active, not recruiting | USA | CAN | 6 |
NCT03329950 | Phase I | CDX-1140 + CDX-301 CDX-1140 | A Study of CDX-1140 as Monotherapy or in Combination in Patients With Advanced Solid Tumors | Recruiting | USA | 0 |
NCT03330405 | Phase II | Avelumab + Talazoparib | Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors | Active, not recruiting | USA | CAN | 7 |
NCT03343613 | Phase I | LY3300054 + LY3381916 LY3381916 | A Study of LY3381916 Alone or in Combination With LY3300054 in Participants With Solid Tumors | Terminated | USA | 5 |
NCT03361228 | Phase Ib/II | Epacadostat + INCB001158 Epacadostat + INCB001158 + Pembrolizumab | A Study to Evaluate the Safety, Tolerability, and Antitumor Activity of INCB001158 Plus Epacadostat, With or Without Pembrolizumab, in Advanced Solid Tumors | Terminated | USA | 0 |
NCT03363776 | Phase Ib/II | BMS-986277 BMS-986277 + Nivolumab | An Immuno-Therapy Study of Experimental Medication BMS-986277 Given Alone and in Combination With Nivolumab in Epithelial Cancers | Terminated | USA | CAN | 0 |
NCT03375307 | Phase II | Olaparib | Olaparib in Treating Patients With Metastatic or Advanced Urothelial Cancer With DNA-Repair Defects | Recruiting | USA | 0 |
NCT03390504 | Phase III | Pembrolizumab Erdafitinib Docetaxel + Vinflunine | A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations | Recruiting | USA | CAN | 29 |
NCT03407976 | Phase Ib/II | Pembrolizumab + Rivoceranib | Apatinib With Pembrolizumab in Previously Treated Advanced Malignancies | Terminated | USA | 0 |
NCT03409458 | Phase Ib/II | Avelumab + Imifoplatin | A Dose Escalation and Confirmation Study of PT-112 in Advanced Solid Tumors in Combination With Avelumab (PAVE-1) | Recruiting | USA | 1 |
NCT03410927 | Phase Ib/II | TAS0728 | A Study of TAS0728 in Patients With Solid Tumors With HER2 or HER3 Abnormalities | Active, not recruiting | USA | 3 |
NCT03416335 | Phase Ib/II | DSP-0509 DSP-0509 + Pembrolizumab | A Study of DSP-0509 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic Profile | Recruiting | USA | 0 |
NCT03419130 | Phase II | Pembrolizumab | Radiation Therapy and Pembrolizumab in Treating Patients With Localized Urothelial Bladder Cancer | Withdrawn | USA | 0 |
NCT03435640 | Phase Ib/II | NKTR-214 + NKTR-262 Nivolumab + NKTR-214 + NKTR-262 | A Study of NKTR-262 in Combination With NKTR-214 and With NKTR-214 Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies | Active, not recruiting | USA | 0 |
NCT03448718 | Phase II | Olaparib | Trial of Olaparib in Patients With Metastatic Urothelial Cancer Harboring DNA Damage Response Gene Alterations | Recruiting | USA | 0 |
NCT03449381 | Phase I | BI 907828 | This Study Aims to Find the Best Dose of BI 907828 in Patients With Different Types of Advanced Cancer (Solid Tumors) | Recruiting | USA | CAN | 1 |
NCT03451331 | Phase II | Carboplatin + Gemcitabine + Nivolumab Gemcitabine + Nivolumab + Oxaliplatin | Gemcitabine + Carboplatin + Nivolumab Versus Gemcitabine + Oxaliplatin + Nivolumab in Cisplatin-ineligible Patients With Metastatic Urothelial Cancer | Recruiting | USA | 0 |
NCT03472560 | Phase II | Avelumab + Axitinib | A Study of Avelumab in Combination With Axitinib In Non-Small Cell Lung Cancer (NSCLC) or Urothelial Cancer (Javelin Medley VEGF) | Active, not recruiting | USA | 7 |
NCT03473743 | Phase Ib/II | Erdafitinib + JNJ-63723283 | A Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Erdafitinib Plus JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Metastatic or Surgically Unresectable Urothelial Cancer With Selected FGFR Gene Alterations | Recruiting | USA | 13 |
NCT03474107 | Phase III | Enfortumab vedotin-ejfv Docetaxel + Paclitaxel + Vinflunine | A Study to Evaluate Enfortumab Vedotin Versus (vs) Chemotherapy in Subjects With Previously Treated Locally Advanced or Metastatic Urothelial Cancer (EV-301) | Active, not recruiting | USA | CAN | 17 |
NCT03486197 | Phase II | Pembrolizumab | Neutron Radiation Therapy and Pembrolizumab in Treating Participants With Advanced Urothelial Carcinoma | Recruiting | USA | 0 |
NCT03517488 | Phase I | XmAb20717 | A Study of XmAb20717 in Subjects With Selected Advanced Solid Tumors (DUET-2) | Recruiting | USA | 0 |
NCT03523572 | Phase I | Nivolumab + Trastuzumab deruxtecan | Trastuzumab Deruxtecan With Nivolumab in Advanced Breast and Urothelial Cancer | Active, not recruiting | USA | 6 |
NCT03525795 | Phase Ib/II | CPI-1205 + Ipilimumab | ORIOn-E: A Study Evaluating CPI-1205 in Patients With Advanced Solid Tumors | Completed | USA | 0 |
NCT03528694 | Phase III | BCG solution + Durvalumab BCG solution | Assessment of Efficacy and Safety of Durvalumab Plus BCG Compared to the Standard Therapy With BCG in Non-muscle Invasive Bladder Cancer | Active, not recruiting | CAN | 12 |
NCT03534804 | Phase II | Cabozantinib + Pembrolizumab | Cabozantinib Plus Pembrolizumab as First-Line Therapy for Cisplatin-Ineligible Advanced Urothelial Carcinoma (PemCab) | Recruiting | USA | 0 |
NCT03538028 | Phase I | INCAGN02385 | A Safety and Tolerability Study of INCAGN02385 in Select Advanced Malignancies | Completed | USA | 0 |
NCT03547973 | Phase II | Sacituzumab govitecan-hziy | Phase II Open Label, Study of IMMU-132 in Metastatic Urothelial Cancer | Recruiting | USA | 1 |
NCT03590054 | Phase I | Abexinostat + Pembrolizumab | A Phase 1b Dose Escalation/Expansion Study of Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies | Recruiting | USA | 0 |
NCT03606174 | Phase II | MGCD516 + Nivolumab | Sitravatinib and Nivolumab in Urothelial Carcinoma Study | Recruiting | USA | 0 |
NCT03621982 | Phase I | Camidanlumab Tesirine | Study of ADCT-301 in Patients With Selected Advanced Solid Tumors | Recruiting | USA | 0 |
NCT03633110 | Phase Ib/II | GEN-009 GEN-009 + Nivolumab | Safety, Tolerability, Immunogenicity, and Antitumor Activity of GEN-009 Adjuvanted Vaccine | Active, not recruiting | USA | 0 |
NCT03639714 | Phase Ib/II | GRT-C901 + GRT-R902 + Ipilimumab + Nivolumab | A Study of a Personalized Neoantigen Cancer Vaccine | Recruiting | USA | 1 |
NCT03666273 | Phase I | BAY1905254 BAY1905254 + Pembrolizumab | A First-in-human Study of ILDR2 (Immunoglobulin-like Domain Containing Receptor 2) Function-blocking Antibody BAY1905254 | Recruiting | USA | 0 |
NCT03674567 | Phase Ib/II | FLX475 + Pembrolizumab FLX475 | Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab | Recruiting | USA | 5 |
NCT03679767 | Phase II | Retifanlimab | A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203) | Active, not recruiting | USA | 7 |
NCT03682289 | Phase II | AZD6738 + Olaparib Olaparib | Phase II Trial of AZD6738 Alone and in Combination With Olaparib | Recruiting | USA | 0 |
NCT03693612 | Phase Ib/II | GSK3359609 + Tremelimumab Paclitaxel Docetaxel Cetuximab | GSK3359609 Plus Tremelimumab for the Treatment of Advanced Solid Tumors | Active, not recruiting | USA | CAN | 1 |
NCT03744793 | Phase II | Avelumab + Pemetrexed Disodium | Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer | Recruiting | USA | 0 |
NCT03752398 | Phase I | XmAb23104 | A Study of XmAb23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) (DUET-3) | Recruiting | USA | 0 |
NCT03758781 | Phase I | Cyclophosphamide + IRX-2 + Nivolumab | IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors | Recruiting | USA | 0 |
NCT03785925 | Phase II | Nivolumab + NKTR-214 | A Single-Arm Study of Bempegaldesleukin (NKTR-214) Plus Nivolumab in Cisplatin Ineligible Patients Who Have Locally Advanced or Metastatic Urothelial Cancer (PIVOT-10) | Active, not recruiting | USA | CAN | 19 |
NCT03809624 | Phase I | INBRX-105 | Study of INBRX-105 in Patients With Solid Tumors (PDL1x41BB) | Recruiting | USA | 0 |
NCT03815682 | Phase I | Pembrolizumab + RPTR-147 RPTR-147 | RPTR-147 in Patients With Selected Solid Tumors and Lymphomas | Recruiting | USA | 0 |
NCT03836352 | Phase II | DPX-Survivac + Pembrolizumab Cyclophosphamide + DPX-Survivac + Pembrolizumab | Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors | Recruiting | USA | CAN | 0 |
NCT03849469 | Phase I | Pembrolizumab + XmAb22841 XmAb22841 | A Study of XmAb22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors (DUET-4) | Recruiting | USA | 0 |
NCT03854474 | Phase Ib/II | Pembrolizumab + Tazemetostat | Tazemetostat and Pembrolizumab in Treating Patients With Locally Advanced or Metastatic Urothelial Carcinoma | Recruiting | USA | CAN | 0 |
NCT03894618 | Phase I | SL-279252 | SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas | Recruiting | USA | CAN | 2 |
NCT03915405 | Phase I | Avelumab + KHK2455 | KHK2455 (IDO Inhibitor) Plus Avelumab in Adult Subjects With Advanced Bladder Cancer | Recruiting | USA | 1 |
NCT03917381 | Phase Ib/II | GEN1046 | GEN1046 Safety Trial in Patients With Malignant Solid Tumors | Recruiting | USA | 4 |
NCT03936959 | Phase I | LY3434172 | A Study of LY3434172, a PD-1 and PD-L1 Bispecific Antibody, in Advanced Cancer | Active, not recruiting | USA | 4 |
NCT03970382 | Phase I | NeoTCR-P1 T-cells + Nivolumab NeoTCR-P1 T-cells | A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid Tumors | Recruiting | USA | 0 |
NCT03973333 | Phase Ib/II | Atezolizumab + IMC-C103C IMC-C103C | Safety and Efficacy of IMC-C103C as Monotherapy and in Combination With Atezolizumab | Recruiting | USA | 2 |
NCT03989362 | Phase II | Ipilimumab + Vopratelimab | Vopratelimab and a CTLA-4 Inhibitor in PD-1/PD-L1 Inhibitor Experienced Subjects With NSCLC or Urothelial Cancer (EMERGE) | Active, not recruiting | USA | CAN | 0 |
NCT03992131 | Phase Ib/II | Lucitanib + Rucaparib Rucaparib + Sacituzumab govitecan-hziy | A Study to Evaluate Rucaparib in Combination With Other Anticancer Agents in Patients With a Solid Tumor (SEASTAR) | Recruiting | USA | 0 |
NCT04003610 | Phase II | Pembrolizumab + Pemigatinib Pembrolizumab Carboplatin + Gemcitabine Pemigatinib | Pemigatinib + Pembrolizumab vs Pemigatinib Alone vs Standard of Care for Urothelial Carcinoma (FIGHT-205) | Active, not recruiting | USA | CAN | 14 |
NCT04007744 | Phase I | Pembrolizumab + Sonidegib | Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors | Recruiting | USA | 0 |
NCT04044859 | Phase I | ADP-A2M4 cells | Surpass: ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Tumors | Recruiting | USA | CAN | 2 |
NCT04095273 | Phase I | BAY1895344 + Pembrolizumab | Study to Test How Well Patients With Advanced Solid Tumors Respond to Treatment With the ATR Inhibitor BAY1895344 in Combination With Pembrolizumab, to Find the Optimal Dose for Patients, How the Drug is Tolerated and the Way the Body Absorbs, Distributes and Discharges the Drug | Recruiting | USA | 4 |
NCT04096638 | Phase I | Nivolumab + SB 11285 SB 11285 | Evaluating Safety and Efficacy of SB 11285 Alone and in Combination With Nivolumab in Patients With Advanced Solid Tumors | Recruiting | USA | 0 |
NCT04114136 | Phase II | Nivolumab Metformin + Nivolumab Pembrolizumab Metformin + Pembrolizumab Pembrolizumab + Rosiglitazone Nivolumab + Rosiglitazone | Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies | Recruiting | USA | 0 |
NCT04149574 | Phase III | BCG solution + Nivolumab BCG solution | A Study Comparing the Efficacy and Safety of Nivolumab in Combination With Bacillus Calmette-Guerin (BCG) Versus BCG Alone in Participants With High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (CheckMate 7G8) | Recruiting | USA | CAN | 17 |
NCT04152018 | Phase I | PF-06801591 + PF-06940434 PF-06940434 | Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors. | Recruiting | USA | 0 |
NCT04158700 | Phase Ib/II | LY3200882 + Pembrolizumab | A Study of LY3200882 and Pembrolizumab in Participants With Advanced Cancer | Withdrawn | USA | 2 |
NCT04173338 | Phase I | Cabozantinib + Pemetrexed Disodium | Cabozantinib With Pemetrexed in Advanced Non-small Cell Lung Cancer, Urothelial Cancer and Malignant Mesothelioma | Recruiting | USA | 0 |
NCT04198766 | Phase I | INBRX-106 INBRX-106 + Pembrolizumab | Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist) | Recruiting | USA | 0 |
NCT04200963 | Phase I | KYN-175 | KYN-175 in Patients With Advanced or Metastatic Solid Tumors and Urothelial Carcinoma | Recruiting | USA | 0 |
NCT04223856 | Phase III | Carboplatin + Enfortumab vedotin-ejfv + Pembrolizumab Cisplatin + Gemcitabine Carboplatin + Gemcitabine Enfortumab vedotin-ejfv + Pembrolizumab Cisplatin + Enfortumab vedotin-ejfv + Pembrolizumab | Enfortumab Vedotin and Pembrolizumab, With or Without Chemotherapy, vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer (EV-302) | Recruiting | USA | CAN | 2 |
NCT04259450 | Phase Ib/II | AFM24 | Study to Assess AFM24 in Advanced Solid Cancers | Recruiting | USA | 2 |
NCT04260802 | Phase Ib/II | OC-001 + unspecified PD-L1 antibody OC-001 + unspecified PD-1 antibody OC-001 | A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers | Recruiting | CAN | 0 |
NCT04311710 | Phase Ib/II | Ipilimumab + Nivolumab Ipilimumab + Nivolumab + rHuPH20 | A Study Evaluating the Drug Levels of Iplimumab Given Under the Skin Alone and in Combination With Nivolumab in Multiple Tumor Types (CheckMate 76U) | Recruiting | USA | 8 |
NCT04322643 | Phase II | Durvalumab Pembrolizumab Avelumab Nivolumab Atezolizumab | Intermittent Checkpoint Inhibitor Therapy In Patients With Advanced Urothelial Carcinoma | Recruiting | USA | 0 |
NCT04349280 | Phase I | M7824 | A Study to Evaluate the Efficacy and Safety of Bintrafusp Alfa (M7824) Monotherapy in Metastatic or Locally Advanced Urothelial Cancer | Recruiting | USA | 3 |
NCT04383938 | Phase Ib/II | APR-246 + Pembrolizumab | Phase 1/2 Study of APR-246 in Combination With Pembrolizumab in Subjects With Solid Tumor Malignancies | Recruiting | USA | 0 |
NCT04388852 | Phase I | DS-3201b + Ipilimumab | DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers | Recruiting | USA | 0 |
NCT04423029 | Phase Ib/II | DF6002 + Pembrolizumab DF6002 | Dose Escalation of DF6002 in Patients With Advanced Solid Tumors, and Expansion in Selected Indications | Recruiting | USA | 0 |
NCT04434560 | Phase II | Ipilimumab + Nivolumab | Neoadjuvant Immunotherapy in Brain Metastases | Recruiting | USA | 0 |
NCT04442126 | Phase Ib/II | NM21-1480 | A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors | Recruiting | USA | 1 |
NCT04452214 | Phase I | Nidanilimab + Pembrolizumab | A Study of the Safety and Tolerance of CAN04 in Combination With Pembrolizumab in Subjects With Solid Tumors | Recruiting | USA | 0 |
NCT04486781 | Phase II | Pembrolizumab + sEphB4-HSA | A Study of Pembrolizumab+ sEphB4 in Metastatic Urothelial Carcinoma | Recruiting | USA | 0 |
NCT04514484 | Phase I | Cabozantinib + Nivolumab | Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV | Recruiting | USA | 0 |
NCT04521413 | Phase Ib/II | CFI-402411 + Pembrolizumab CFI-402411 | Safety and Efficacy Study Of CFI-402411 in Subjects With Advanced Solid Malignancies | Recruiting | USA | CAN | 1 |
NCT04527991 | Phase III | Paclitaxel Docetaxel Vinflunine Sacituzumab govitecan-hziy | Study of Sacituzumab Govitecan (IMMU-132) in Metastatic or Locally Advanced Unresectable Urothelial Cancer (TROPiCS-04) | Recruiting | USA | 1 |
NCT04543110 | Phase II | Durvalumab | Radiation and Durvalumab Immunotherapy As Neoadjuvant Treatment for MIBC (RADIANT) | Recruiting | CAN | 0 |
NCT04561362 | Phase Ib/II | BT8009 BT8009 + Nivolumab | Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Solid Tumors Malignancies | Recruiting | USA | 1 |
NCT04565275 | Phase Ib/II | ICP-192 | A Study of ICP-192 in Patients With Advanced Solid Tumors | Recruiting | USA | 0 |
NCT04601402 | Phase I | Avelumab + GEN-001 | GEN-001 (Live Biotherapeutic Product) and Avelumab Combination Study for Patients With Solid Tumors Who Have Progressed on Anti-PD-(L)1 Therapy | Recruiting | USA | 0 |
NCT04601857 | Phase II | Futibatinib + Pembrolizumab | Futibatinib and Pembrolizumab Combination in the Treatment of Advanced or Metastatic Urothelial Carcinoma | Recruiting | USA | 0 |
NCT04639245 | Phase Ib/II | MAGE-A1-specific TCR cells + unspecified PD-1 antibody Cyclophosphamide + Fludarabine Atezolizumab + MAGE-A1-specific TCR cells MAGE-A1-specific TCR cells | Genetically Engineered Cells (MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells) and Atezolizumab for the Treatment of Metastatic Triple Negative Breast Cancer, Urothelial Cancer, or Non-small Cell Lung Cancer | Not yet recruiting | USA | 0 |
NCT04701918 | Phase II | Pembrolizumab | Pembrolizumab And Cryoablation In Urothelial Carcinoma | Not yet recruiting | USA | 0 |