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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MTIG7192A||RO7092284|RG6058|Tiragolumab||Immune Checkpoint Inhibitor 136 TIGIT Antibody 10||Tiragolumab (MTIG7192A) is an anti-human TIGIT (T cell immunoreceptor with Ig ITIM domain) antibody that potentially has anti-tumor activities through modulating the immune response to tumors (PMID: 29991503, PMID: 32576590).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04045028||Phase I||MTIG7192A Daratumumab + MTIG7192A MTIG7192A + Rituximab||A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Preliminary Activity of Tiragolumab in Participants With Relapsed or Refractory Multiple Myeloma or With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma||Recruiting||USA||1|
|NCT02794571||Phase I||Atezolizumab + MTIG7192A MTIG7192A||Safety and Pharmacokinetics (PK) of Escalating Doses of MTIG7192A as a Single Agent and in Combination With Atezolizumab in Locally Advanced or Metastatic Tumors||Recruiting||USA | CAN||5|