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Therapy Name | Bicalutamide |
Synonyms | |
Therapy Description |
Casodex (bicalutamide) is an androgen-receptor antagonist that binds androgen receptors and inhibits androgen binding, therefore inhibits AR-dependent growth of tumor cells (PMID: 9428389). Casodex (bicalutamide) is approved, in combination with a luteinizing hormone-releasing hormone (LHRH) analog, for metastatic carcinoma of the prostate (FDA.gov). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Bicalutamide | Casodex | Hormone - Anti-androgens 39 | Casodex (bicalutamide) is an androgen-receptor antagonist that binds androgen receptors and inhibits androgen binding, therefore inhibits AR-dependent growth of tumor cells (PMID: 9428389). Casodex (bicalutamide) is approved, in combination with a luteinizing hormone-releasing hormone (LHRH) analog, for metastatic carcinoma of the prostate (FDA.gov). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT02614859 | Phase II | Bicalutamide Metformin | Bicalutamide With or Without Metformin for Biochemical Recurrence in Overweight or Obese Prostate Cancer Patients | Completed | USA | 0 |
NCT05050084 | Phase III | Buserelin Relugolix Degarelix Goserelin Leuprolide Histrelin acetate Triptorelin Darolutamide + Goserelin Bicalutamide Darolutamide + Degarelix Darolutamide + Leuprolide Darolutamide + Triptorelin Buserelin + Darolutamide Darolutamide + Histrelin acetate Flutamide Darolutamide + Relugolix | Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score | Recruiting | USA | CAN | 0 |
NCT01809691 | Phase III | Orteronel Bicalutamide | S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer | Active, not recruiting | USA | 0 |
NCT02366494 | Phase I | Leuprolide Goserelin Triptorelin Bicalutamide Docetaxel | Micro RNAs to Predict Response to Androgen Deprivation Therapy | Active, not recruiting | USA | 0 |
NCT00541047 | Phase III | Leuprolide Goserelin Bicalutamide | Radiation Therapy and Androgen Deprivation Therapy in Treating Patients Who Have Undergone Surgery for Prostate Cancer (RADICALS) | Unknown status | CAN | 1 |
NCT02059213 | Phase II | Goserelin Palbociclib Bicalutamide Leuprolide | A Phase II Study of Androgen Deprivation Therapy With or Without PD 0332991 in RB-Positive Metastatic Prostate Cancer | Completed | USA | 0 |
NCT01420250 | Phase I | Bicalutamide Cabazitaxel | Cabazitaxel With Radiation and Hormone Therapy for Prostate Cancer | Active, not recruiting | USA | 0 |
NCT03147196 | Phase II | Bicalutamide + Raloxifene Raloxifene Bicalutamide | Bicalutamide and Raloxifene Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery | Withdrawn | 0 | |
NCT02531516 | Phase III | Abiraterone + Apalutamide + Prednisone Bicalutamide | An Efficacy and Safety Study of JNJ-56021927 (ARN-509) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy | Active, not recruiting | USA | FRA | ESP | DEU | CAN | BEL | 17 |
NCT01674270 | Phase II | Bicalutamide Degarelix | Degarelix Neo-Adjuvant Radical Prostatectomy Trial | Completed | CAN | 0 |
NCT01342367 | Phase I | Bicalutamide Dutasteride Finasteride | Feasibility of Hormones and Radiation for Intermediate or High Risk Prostate Cancer | Active, not recruiting | USA | 0 |
NCT02058706 | Phase II | Goserelin Bicalutamide Enzalutamide Leuprolide | LHRH Analogue Therapy With Enzalutamide or Bicalutamide in Treating Patients With Metastatic Hormone Sensitive Prostate Cancer | Active, not recruiting | USA | 0 |
NCT02799706 | Phase III | Flutamide Degarelix Bicalutamide | Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer (PEGASUS) | Recruiting | ITA | FRA | ESP | DEU | BEL | 3 |
NCT02064036 | Phase I | Bicalutamide Goserelin Leuprolide | Stereotactic Boost and Long-Term Androgen Deprivation for Adenocarcinoma of the Prostate | Completed | USA | 0 |
NCT00936390 | Phase III | Flutamide Goserelin Leuprolide Triptorelin Bicalutamide | Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer | Active, not recruiting | USA | CAN | 0 |
NCT02346253 | Phase Ib/II | Leuprolide Triptorelin Degarelix Bicalutamide Goserelin | High-Dose Brachytherapy in Treating Patients With Prostate Cancer | Active, not recruiting | USA | 0 |
NCT03678025 | Phase III | Docetaxel Nilutamide Triptorelin Bicalutamide Leuprolide Degarelix Goserelin Flutamide Prednisone Abiraterone Histrelin acetate | Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer | Recruiting | USA | 2 |
NCT00002651 | Phase III | Bicalutamide Goserelin | Hormone Therapy in Treating Men With Stage IV Prostate Cancer | Completed | CAN | 0 |
NCT04025372 | Phase II | Bicalutamide Darolutamide | INTREPId (INTermediate Risk Erection PreservatIon Trial) | Recruiting | USA | 0 |
NCT02582749 | Phase II | Bicalutamide + Radium Ra 223 dichloride Bicalutamide | Androgen Deprivation Therapy +/- Radium-223 Dichloride in Metastatic Prostate Cancer With Bone Metastases | Terminated | USA | 0 |
NCT03809000 | Phase II | Goserelin Bicalutamide Enzalutamide Leuprolide | A Trial to See What the Results Are for Radiation Therapy and Hormone Therapy vs Radiation Therapy With Enhanced Hormone Therapy With Enzalutamide for Patients With PSA Recurrence After Surgery (STEEL) | Recruiting | USA | CAN | 0 |