Therapy Detail

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Therapy Name Itraconazole
Synonyms
Therapy Description

Itraconazole is an antifungal, which indirectly targets mTOR (PMID: 20176935).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Itraconazole Hyphanox ITC mTOR Inhibitor 51 Itraconazole is an antifungal, which indirectly targets mTOR (PMID: 20176935).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown ovarian cancer not applicable Itraconazole Phase I Actionable In a Phase I clinical trial, Itraconazole, in combination with chemotherapy, demonstrated safety and efficacy in patients with ovarian cancer (PMID: 24778064). 24778064
Unknown unknown renal cell carcinoma not applicable Itraconazole Preclinical - Cell culture Actionable In a preclinical study, Itraconazole resulted in antiangiogenic activity and inhibited cell proliferation of renal carcinoma cells in culture (PMID: 22025615). 22025615

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  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status
NCT02253420 Phase I Copanlisib Itraconazole COPANLISIB (BAY80-6946) Drug-drug Interaction Study in Advanced Solid Tumor Patients Completed
NCT02122770 Phase I Paclitaxel Docetaxel Itraconazole Carboplatin MLN4924 Fluconazole Effects of Fluconazole and Itraconazole CYP3A-Mediated Inhibition on the Pharmacokinetics, Safety, and Tolerability of MLN4924 in Patients With Advanced Solid Tumors Completed
NCT02749513 Phase I Itraconazole Itraconazole as a Targeted Therapy for Inhibiting Hedgehog Pathway Signaling in Esophageal Cancer Patients Active, not recruiting
NCT02735356 Phase I Itraconazole Topical Itraconazole in Treating Patients With Basal Cell Cancer Completed
NCT02120677 Phase I Itraconazole Topical Itraconazole in the Treatment of Basal Cell Carcinoma Completed
NCT02259010 Phase I Alisertib Itraconazole A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics of Alisertib in Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma Completed
NCT02457351 Phase I Roniciclib Itraconazole Roniciclib (BAY 1000394) Drug-Drug Interaction (DDI) Study Completed
NCT04018872 Phase II Itraconazole Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer Recruiting
NCT01787331 Phase II Itraconazole A Phase II Study of Itraconazole in Biochemical Relapse Completed
NCT02357836 Phase I Itraconazole Neoadjuvant Itraconazole in Non-small Cell Lung Cancer Completed


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