Therapy Detail

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Therapy Name Itraconazole
Synonyms
Therapy Description

Itraconazole is an antifungal, which indirectly targets mTOR (PMID: 20176935).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Itraconazole Hyphanox ITC mTOR Inhibitor 51 Itraconazole is an antifungal, which indirectly targets mTOR (PMID: 20176935).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01787331 Phase II Itraconazole A Phase II Study of Itraconazole in Biochemical Relapse Completed USA 0
NCT03458221 Phase II Itraconazole Everolimus Letrozole Bicalutamide Signal TrAnsduction Pathway Activity Analysis in OVarian cancER (STAPOVER) Recruiting NLD 0
NCT02259010 Phase I Alisertib Itraconazole A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics of Alisertib in Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma Completed USA 0
NCT02253420 Phase I Copanlisib Itraconazole COPANLISIB (BAY80-6946) Drug-drug Interaction Study in Advanced Solid Tumor Patients Completed USA | CAN 0
NCT02749513 Phase I Itraconazole Itraconazole as a Targeted Therapy for Inhibiting Hedgehog Pathway Signaling in Esophageal Cancer Patients Unknown status USA 0
NCT02122770 Phase I Paclitaxel Docetaxel Itraconazole Carboplatin MLN4924 Fluconazole Effects of Fluconazole and Itraconazole CYP3A-Mediated Inhibition on the Pharmacokinetics, Safety, and Tolerability of MLN4924 in Patients With Advanced Solid Tumors Completed USA 0
NCT02735356 Phase I Itraconazole Topical Itraconazole in Treating Patients With Basal Cell Cancer Completed USA 0
NCT02120677 Phase I Itraconazole Topical Itraconazole in the Treatment of Basal Cell Carcinoma Completed USA 0
NCT02457351 Phase I Roniciclib Itraconazole Roniciclib (BAY 1000394) Drug-Drug Interaction (DDI) Study Completed CAN 0
NCT02357836 Phase I Itraconazole Neoadjuvant Itraconazole in Non-small Cell Lung Cancer Completed USA 0
NCT04018872 Phase II Itraconazole Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer Recruiting USA 0
NCT05563766 Phase II Itraconazole A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer Not yet recruiting USA 0


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