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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|GEN1046||GEN-1046|GEN 1046|DuoBody-PD-L1x4-1BB|BNT 311||PD-L1/PD-1 antibody 62||GEN1046 is a bispecific antibody that binds to and simultaneously targets PD-L1 and TNFRSF9 (4-1BB), potentially resulting in the activation of T-lymphocytes, leading to increased anti-tumor immune response and decreased tumor growth (J. Immunotherapy Cancer, 6, 115 (2018), Abs nr: P647).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT03917381||Phase Ib/II||GEN1046||GEN1046 Safety Trial in Patients With Malignant Solid Tumors||Recruiting|