Molecular Profile Detail


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Profile Name TP53 over exp
Gene Variant Detail

TP53 over exp (no effect)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 over exp ovarian cancer predicted - sensitive HLA-A2 p53:264-272 vaccine Phase I Actionable In a Phase I trial, the HLA-A2 p53:264-272 vaccine demonstrated safety and preliminary efficacy in patients with TP53 overexpressing ovarian cancer, resulting in a progression-free survival of 5.5 months and an overall survival of 40.4 months (PMID: 21927947). 21927947
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02432963 Phase I MVAp53 + Pembrolizumab Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy Active, not recruiting USA 0