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|Profile Name||FLT3 S451F|
|Gene Variant Detail|
|Relevant Treatment Approaches||FLT3 Inhibitor|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FLT3 S451F||Advanced Solid Tumor||decreased response||FLT3 Inhibitor||Midostaurin||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells expressing FLT3 S451F demonstrated decreased sensitivity to inhibition of FLT3 phosphorylation and growth by Rydapt (midostaurin) in culture, when compared to cells expressing other FLT3 activating mutations (PMID: 18068628).||18068628|