Molecular Profile Detail


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Profile Name FLT3 S451F
Gene Variant Detail

FLT3 S451F (gain of function)

Relevant Treatment Approaches FLT3 Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 S451F Advanced Solid Tumor decreased response FLT3 Inhibitor Midostaurin Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing FLT3 S451F demonstrated decreased sensitivity to inhibition of FLT3 phosphorylation and growth by Rydapt (midostaurin) in culture, when compared to cells expressing other FLT3 activating mutations (PMID: 18068628). 18068628
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries