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Molecular Profile | BRAF wild-type |
Therapy | PLX4720 |
Indication/Tumor Type | melanoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF wild-type | melanoma | resistant | PLX4720 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, PLX4720 did not inhibit growth of BRAF wild-type melanoma cells in culture or in cell line xenograft models (PMID: 18287029). | 18287029 |
PubMed Id | Reference Title | Details |
---|---|---|
(18287029) | Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. | Full reference... |