Profile Response Detail


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Molecular Profile BRAF V600K
Therapy Dabrafenib + Trametinib
Indication/Tumor Type melanoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600K melanoma sensitive Dabrafenib + Trametinib FDA approved - On Companion Diagnostic Actionable In a Phase III trial (COMBI-v) that supported FDA approval, the combination of Tafinlar (dabrafenib) and Mekinist (trametinib) resulted in an improved overall survival rate at 12 months (72% vs 65%, HR=0.69, p=0.005), median progression-free survival (11.4 vs 7.3 months, HR=0.56, p<0.001), and objective response rate (64% vs 51%, p<0.001) compared to Zelboraf (vemurafenib) in melanoma patients harboring BRAF V600E or V600K (PMID: 25399551; NCT01597908). detail... 25399551 detail...
PubMed Id Reference Title Details
(25399551) Improved overall survival in melanoma with combined dabrafenib and trametinib. Full reference...
Full reference...
Tafinlar (dabrafenib) FDA Drug Label Full reference...