Profile Response Detail

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Molecular Profile BRAF V600K
Therapy Binimetinib + Encorafenib
Indication/Tumor Type skin melanoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600K skin melanoma sensitive Binimetinib + Encorafenib Guideline Actionable Braftovi (encorafenib) in combination with Mektovi (binimetinib) is included in guidelines as first-line and second-line therapy for patients with metastatic or unresectable cutaneous melanoma harboring BRAF V600E or V600K mutations (PMID: 30959471; NCCN.org). 30959471 detail...
PubMed Id Reference Title Details
NCCN.org Full reference...
(30959471) Cutaneous Melanoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. Full reference...