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Molecular Profile | HRAS G12V |
Therapy | WM-8014 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
HRAS G12V | Advanced Solid Tumor | sensitive | WM-8014 | Preclinical | Actionable | In a preclinical study, WM-8014 inhibited proliferation of a transformed mouse cell line expressing HRAS G12V in culture, and inhibited proliferation and induced senescence in a transgenic zebrafish model (PMID: 30069049). | 30069049 |
PubMed Id | Reference Title | Details |
---|---|---|
(30069049) | Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. | Full reference... |