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Molecular Profile | RET fusion |
Therapy | Selpercatinib |
Indication/Tumor Type | thyroid gland cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET fusion | thyroid gland cancer | sensitive | Selpercatinib | FDA approved - On Companion Diagnostic | Actionable | In a Phase I/II trial (LIBRETTO-001) that supported FDA approval, Retevmo (selpercatinib) treatment resulted in an objective response rate of 79% (15/19), including one complete and 14 partial responses, with a median response duration of 18.4 months, and median progression-free survival of 20.1 months in adult and pediatric patients 12 years and older with RET fusion-positive thyroid cancer who were previously treated (PMID: 32846061; NCT03157128). | detail... detail... 32846061 |
PubMed Id | Reference Title | Details |
---|---|---|
Full reference... | ||
Retevmo (selpercatinib) FDA Drug Label | Full reference... | |
(32846061) | Efficacy of Selpercatinib in RET-Altered Thyroid Cancers. | Full reference... |