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Molecular Profile CDKN2A del
Therapy unspecified immune checkpoint inhibitor
Indication/Tumor Type renal cell carcinoma
Response Type not predictive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDKN2A del renal cell carcinoma not predictive unspecified immune checkpoint inhibitor Clinical Study - Cohort Actionable In a retrospective analysis, homozygous deletion of CDKN2A or loss of function CDKN2A mutations in one cohort of renal cell carcinoma patients were not predictive of overall survival or time to treatment failure when treated with immune checkpoint inhibitors, but in another cohort were significantly associated with reduced overall survival compared to wild-type CDKN2A (13 months vs 50 months, P=0.002)(PMID: 34074656). 34074656
PubMed Id Reference Title Details
(34074656) CDKN2A Alterations and Response to Immunotherapy in Solid Tumors. Full reference...