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Molecular Profile PALB2 inact mut
Therapy Olaparib
Indication/Tumor Type estrogen-receptor positive breast cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PALB2 inact mut estrogen-receptor positive breast cancer sensitive Olaparib Guideline Actionable Lynparza (olaparib) is included in guidelines as second-line therapy for patients with ESR1 (ER)-positive, ERBB2 (HER2)-negative metastatic breast cancer with germline or somatic pathogenic/likely pathogenic PALB2 mutations who have progressed on an endocrine therapy plus CDK4/6 inhibitor (PMID: 34678411; detail... 34678411
PubMed Id Reference Title Details
ESMO Clinical Practice Guidelines Full reference...
(34678411) ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer. Full reference...