Disease Detail

ID DOID:60075
Name estrogen-receptor positive breast cancer
Definition A breast cancer that is characterized by the presence of estrogen receptors.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer thoracic cancer breast cancer estrogen-receptor positive breast cancer

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
FGFR1 amp Dovitinib estrogen-receptor positive breast cancer sensitive detail...
FGFR1 amp Cediranib estrogen-receptor positive breast cancer sensitive detail...
FGFR1 amp Nintedanib estrogen-receptor positive breast cancer sensitive detail...
FGFR1 amp Brivanib estrogen-receptor positive breast cancer no benefit detail...
ERBB2 act mut Vistusertib estrogen-receptor positive breast cancer predicted - sensitive detail...
Unknown unknown Everolimus estrogen-receptor positive breast cancer not applicable detail...
Unknown unknown Everolimus + Tamoxifen estrogen-receptor positive breast cancer not applicable detail...
PTEN inact mut Pictilisib estrogen-receptor positive breast cancer sensitive detail...
PTEN inact mut Fulvestrant + Pictilisib estrogen-receptor positive breast cancer sensitive detail...
FGFR1 amp E7090 estrogen-receptor positive breast cancer sensitive detail...
Unknown unknown RO6839921 estrogen-receptor positive breast cancer not applicable detail...
FGFR1 amp Alpelisib estrogen-receptor positive breast cancer resistant detail...
FGFR1 amp Lucitanib estrogen-receptor positive breast cancer sensitive detail...
RB1 loss Palbociclib estrogen-receptor positive breast cancer resistant detail...
Unknown unknown ICEC0942 + Tamoxifen estrogen-receptor positive breast cancer sensitive detail...
AKT1 E17K Capivasertib estrogen-receptor positive breast cancer predicted - sensitive detail...
RB1 mutant Palbociclib estrogen-receptor positive breast cancer predicted - resistant detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00570323 Phase II Anastrozole + Fulvestrant Anastrozole Arimidex With or Without Faslodex In Postmenopausal Women With HR Positive Breast Cancer Active, not recruiting
NCT00759642 Phase II Lapatinib Lapatinib in Women With Metastatic Breast Cancer Who Have Failed Prior Antihormone Therapy Unknown status
NCT01027416 Phase I Tamoxifen Analyzing a New Mechanism in Response to Tamoxifen Therapy in Breast Cancer Patients Completed
NCT01177397 Phase Ib/II CC-223 Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma Completed
NCT01219699 Phase I Alpelisib Fulvestrant A Study of BYL719 in Adult Patients With Advanced Solid Malignancies, Whose Tumors Have an Alteration of the PIK3CA Gene Active, not recruiting
NCT01587703 Phase I GSK525762 A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers Active, not recruiting
NCT01594216 Phase II Exemestane + Ruxolitinib Ruxolitinib in Estrogen Receptor Positive Breast Cancer Completed
NCT01857193 Phase Ib/II Everolimus + Exemestane + Ribociclib Exemestane + Ribociclib Phase Ib Trial of LEE011 With Everolimus (RAD001) and Exemestane in the Treatment of Hormone Receptor Positive HER2 Negative Advanced Breast Cancer Active, not recruiting
NCT01872260 Phase I Alpelisib + Letrozole Alpelisib + Letrozole + Ribociclib Letrozole + Ribociclib Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer Active, not recruiting
NCT01990209 Phase II Orteronel Orteronel as Monotherapy in Patients With Metastatic Breast Cancer (MBC) That Expresses the Androgen Receptor (AR) Recruiting
NCT02049957 Phase Ib/II Fulvestrant + Sapanisertib Exemestane + Sapanisertib Safety and Efficacy Study of MLN0128 in Combination With Exemestane or Fulvestrant in Postmenopausal Women With ER/PR+ Metastatic Breast Cancer Completed
NCT02219789 Phase I Fulvestrant Alisertib Alisertib and Fulvestrant in Treating Patients With Hormone Receptor Positive Breast Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Completed
NCT02308020 Phase II Abemaciclib A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain Active, not recruiting
NCT02395627 Phase II Pembrolizumab + Tamoxifen + Vorinostat Reversing Hormone Therapy Resistance With Epigenetic-Immune Modification Active, not recruiting
NCT02569801 Phase II GDC-0810 Fulvestrant A Study of GDC-0810 Versus Fulvestrant in Women With Advanced or Metastatic Breast Cancer Resistant to Aromatase Inhibitor Therapy Active, not recruiting
NCT02580448 Phase Ib/II VT-464 A Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of VT-464 in Patients With Advanced Breast Cancer Completed
NCT02598557 Phase II Exemestane Alternative Dosing of Exemestane Before Surgery in Treating Postmenopausal Patients With Stage 0-II Estrogen Positive Breast Cancer Recruiting
NCT02676986 Phase II Enzalutamide + Exemestane Enzalutamide Short-term Preoperative Treatment With Enzalutamide, Alone or in Combination With Exemestane in Primary Breast Cancer (ARB) Active, not recruiting
NCT02734615 Phase I Alpelisib + LSZ 102 LSZ 102 + Ribociclib LSZ 102 Phase I/Ib Trial of LSZ102 Single Agent or LSZ102 + LEE011 or LSZ102 + BYL719 in ER+ Breast Cancers Recruiting
NCT02783300 Phase I GSK3326595 Dose Escalation Study of GSK3326595 in Subjects With Solid Tumors and Non-Hodgkin's Lymphoma Recruiting
NCT02820961 Phase I Entinostat + Exemestane Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast Cancer Active, not recruiting
NCT02913430 Phase II Tamoxifen Fulvestrant Phase II Treatment of Metastatic Breast Cancer With Fulvestrant or Tamoxifen Recruiting
NCT02988986 Phase II Sapanisertib + Tamoxifen TAK-228 Plus Tamoxifen in Patients With ER-Positive, HER2-negative Breast Cancer Completed
NCT03092635 Phase I Metformin + OPC AGE Levels in ER+ Metastatic Breast Cancer Patients Receiving Endocrine Therapy Recruiting
NCT03201913 Phase I TTC-352 Study of TTC-352 in Patients With Metastatic Breast Cancer Progressing on Endocrine Therapy Recruiting
NCT03250676 Phase Ib/II H3B-6545 Trial of H3B-6545, a Covalent Antagonist of Estrogen Receptor Alpha, in Women With Locally Advanced or Metastatic Estrogen Receptor-positive, HER2 Negative Breast Cancer Recruiting
NCT03289039 Neratinib Fulvestrant + Neratinib A Phase 2 Study of Neratinib With or Without Fulvestrant in HER2-Positive, ER-Positive Metastatic Breast Cancer Recruiting
NCT03321981 Phase II Letrozole + MCLA-128 Anastrozole + MCLA-128 Fulvestrant + MCLA-128 Exemestane + MCLA-128 MCLA-128 + Trastuzumab MCLA-128 + Trastuzumab + Vinorelbine MCLA-128 With Trastuzumab/Chemotherapy in HER2+ and With Endocrine Therapy in ER+ and Low HER2 Breast Cancer Recruiting
NCT03330405 Phase II Avelumab + Talazoparib Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors Recruiting
NCT03361800 Entinostat Window of Opportunity Trial of Entinostat in Patients With Newly Diagnosed Stage I-IIIC,TNBC Recruiting
NCT03366844 Phase I Pembrolizumab Pilot; Open Label; Breast Cancer; Preoperative Pembrolizumab + Radiation Recruiting
NCT03573648 Phase II Avelumab + Palbociclib + Tamoxifen Avelumab + Tamoxifen Neoadjuvant Tamoxifen, Palbociclib, Avelumab in Estrogen Receptor Positive Breast Cancer (ImmunoADAPT) Recruiting
NCT03584009 Phase II Fulvestrant Fulvestrant + Venetoclax A Phase II Study Comparing The Efficacy Of Venetoclax + Fulvestrant Vs. Fulvestrant In Women With Estrogen Receptor-Positive, Her2-Negative Locally Advanced Or Metastatic Breast Cancer Who Experienced Disease Recurrence Or Progression During Or After CDK4/6 Inhibitor Therapy Recruiting
NCT03874325 Phase II Durvalumab + Exemestane Durvalumab + Letrozole Anastrozole + Durvalumab Aromatase Inhibitor and Durvalumab in Postmenopausal Breast Cancer Recruiting