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Molecular Profile | RET V804M RET Y806C |
Therapy | Selpercatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET V804M RET Y806C | Advanced Solid Tumor | decreased response | Selpercatinib | Preclinical - Biochemical | Actionable | In a preclinical study, transformed human cells expressing RET V804M and Y806C in cis were less sensitive to Retevmo (selpercatinib) in culture (PMID: 35304457). | 35304457 |
PubMed Id | Reference Title | Details |
---|---|---|
(35304457) | The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers. | Full reference... |