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Molecular Profile | BRAF V600E |
Therapy | Cobimetinib + Vemurafenib |
Indication/Tumor Type | breast cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | breast cancer | predicted - sensitive | Cobimetinib + Vemurafenib | Case Reports/Case Series | Actionable | In a Phase II trial (TAPUR), Zelboraf (vemurafenib) and Cotellic (cobimetinib) combination therapy resulted in a complete response lasting 108.9 weeks in a patient with advanced breast cancer harboring BRAF V600E (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 3008; NCT02693535). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Cobimetinib plus vemurafenib (C+V) in patients (Pts) with solid tumors with BRAF V600E/d/k/R mutation: Results from the targeted agent and profiling utilization registry (TAPUR) study. | Full reference... |