Profile Response Detail


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Molecular Profile PIK3CA H1047R
Therapy Alpelisib
Indication/Tumor Type endometrial cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA H1047R endometrial cancer predicted - sensitive Alpelisib Case Reports/Case Series Actionable In a clinical case study, Piqray (alpelisib) resulted in a partial response after 4 months in a patient with endometrial endometrioid cancer harboring PIK3CA H1047R, with treatment ongoing at 7 months (PMID: 36713525). 36713525
PIK3CA H1047R endometrial cancer predicted - sensitive Alpelisib Case Reports/Case Series Actionable In a clinical study, Piqray (alpelisib) treatment was well tolerated and demonstrated activity in patients with advanced gynecologic cancer harboring activating mutations in PIK3CA and resulted in an overall response rate (ORR) of 28% (10/36), with an ORR of 35% (6/17, all partial responses) in endometrial cancer patients, including disease control in 7 of 9 patients harboring PIK3CA H1047R (PMID: 38518529; NCT04085653). 38518529
PubMed Id Reference Title Details
(36713525) The way to precision medicine in gynecologic cancers: The first case report of an exceptional response to alpelisib in a PIK3CA-mutated endometrial cancer. Full reference...
(38518529) Alpelisib for PIK3CA-mutated advanced gynecological cancers: First clues of clinical activity. Full reference...