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Molecular Profile | IDH2 R140Q |
Therapy | HMPL-306 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH2 R140Q | Advanced Solid Tumor | predicted - sensitive | HMPL-306 | Preclinical - Biochemical | Actionable | In a preclinical study, HMPL-306 inhibited the enzymatic activity of IDH2 R140Q in a fluorescence-based assay (Cancer Res (2023) 83 (7_Supplement): 543). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract 543: Preclinical characteristic of HMPL-306, a CNS-penetrable dual inhibitor of mutant IDH1 and IDH2 | Full reference... |