Profile Response Detail

Molecular Profile FLT3 exon 14 ins FLT3 F691L FLT3 D839N
Therapy Pexidartinib
Indication/Tumor Type Advanced Solid Tumor
Response Type resistant
Create By c-seddy
Update By spatt


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 F691L FLT3 D839N Advanced Solid Tumor resistant Pexidartinib Preclinical Actionable In a preclinical study, transformed cells expressing a compound FLT3-ITD/F691L/D839N were resistant to PLX3397 in culture (PMID: 25847190). 25847190
PubMed Id Reference Title Details
(25847190) Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Full reference...