Profile Response Detail

Molecular Profile ALK Y1278S
Therapy Brigatinib
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By cstatz
Update By tyin


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK Y1278S Advanced Solid Tumor sensitive Brigatinib Preclinical - Cell culture Actionable In a preclinical study, a transformed cell line expressing ALK Y1278S was sensitive to Alunbrig (brigatinib) in culture, resulting in cell growth inhibition (PMID: 27049722). 27049722
PubMed Id Reference Title Details
(27049722) Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice. Full reference...