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Molecular Profile KMT2A rearrange
Therapy N/A
Indication/Tumor Type acute myeloid leukemia
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A rearrange acute myeloid leukemia not applicable N/A Clinical Study Prognostic In multiple clinical studies, KMT2A rearrangements, specifically partial tandem duplications, were associated with a poor overall survival in acute myeloid leukemia patients (PMID: 24487413, PMID: 22915647, PMID: 22417203, PMID: 21881046). 21881046 24487413 22417203 22915647
KMT2A rearrange acute myeloid leukemia not applicable N/A Guideline Prognostic KMT2A rearrangements (t(v;11q23.3)) are associated with a poor/adverse prognosis in patients with non-APL acute myeloid leukemia ( detail...
PubMed Id Reference Title Details
(22915647) A novel hierarchical prognostic model of AML solely based on molecular mutations. Full reference...
(21881046) Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Full reference...
(24487413) Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. Full reference...
(22417203) Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. Full reference... Full reference...