Profile Response Detail

Molecular Profile BRAF V600E BRAF T529I
Therapy CI-1040
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By c-seddy
Update By c-seddy

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E BRAF T529I Advanced Solid Tumor sensitive CI-1040 Preclinical Actionable In a preclinical study, CI-1040 (PD184352) inhibited Erk phosphorylation in transformed cells expressing BRAF V600E and the gatekeeper mutation BRAF T529I in culture (PMID: 20538618). 20538618
PubMed Id Reference Title Details
(20538618) Gatekeeper mutations mediate resistance to BRAF-targeted therapies. Full reference...