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Title | Early detection of a metabolic tumor response to p70S6 kinase/AKT inhibition by LYS6KAKT1 using in vivo choline proton magnetic resonance spectroscopy. | ||||||||||||
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URL | http://mct.aacrjournals.org/content/10/11_Supplement/B117.short | ||||||||||||
Abstract Text | Abstract B117 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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LYS6KAKT1 | Akt Inhibitor (Pan) 21 AKT Inhibitor (Pan) - ATP competitive 7 S6 Kinase Inhibitor 5 | LYS6KAKT1 is an ATP-competitive inhibitor of AKT and p70 S6 kinases, which prevents signaling of the PI3K/AKT pathway and may result in decreased tumor volume and slowed tumor growth (Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B117). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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