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PMID | (32577845) | ||||||||||||
Authors | Hinze A, Rinke J, Hochhaus A, Ernst T | ||||||||||||
Title | Durable remission with ruxolitinib in a chronic neutrophilic leukemia patient harboring a truncation and membrane proximal CSF3R compound mutation. | ||||||||||||
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Abstract Text |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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CSF3R T618I CSF3R Q749* | chronic neutrophilic leukemia | predicted - sensitive | Ruxolitinib | Case Reports/Case Series | Actionable | In a clinical case study, Jakafi (ruxolitinib) treatment resulted in hematologic remission for at least 3 years in a patient with chronic neutrophilic leukemia harboring CSF3R T618I and Q749* along with DNMT3A R882C (PMID: 32577845). | 32577845 |