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Ref Type
PMID
Authors David J. Matthews
Title Preclinical characterization of PWT33597, a dual inhibitor of PI3-kinase alpha and mTOR
Journal Cancer Res
Vol
Issue
Date
URL http://cancerres.aacrjournals.org/content/71/8_Supplement/4485.short
Abstract Text Cancer Res 2011;71(8 Suppl):Abstract nr 4485. doi:10.1158/1538-7445.AM2011-4485

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
PWT33597 PWT33597 2 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
PWT33597 mTOR Inhibitor 51 PIK3CA inhibitor 16 PWT33597 is a dual PIK3CA and mTOR inhibitor, which may induce apoptosis in cells with activated PI3K or mTOR pathways (Cancer Res 2011;71(8 Suppl):Abstract nr 4485).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA mutant colon cancer sensitive PWT33597 Preclinical Actionable In a preclinical study, PWT33597 decreased signaling of mTOR and PIK3 pathways in colon cancer cells with Pik3ca mutations (Cancer Res 2011;71(8 Suppl):Abstract nr 4485). detail...
PIK3CA mutant lung non-small cell carcinoma sensitive PWT33597 Preclinical Actionable In a preclinical study, PWT33597 decreased signaling of mTOR and PIK3 pathways in non-small cell lung cancer cells with Pik3ca mutations (Cancer Res 2011;71(8 Suppl):Abstract nr 4485). detail...