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Ref Type | |
PMID | |
Authors | David J. Matthews |
Title | Preclinical characterization of PWT33597, a dual inhibitor of PI3-kinase alpha and mTOR |
Journal | Cancer Res |
Vol | |
Issue | |
Date | |
URL | http://cancerres.aacrjournals.org/content/71/8_Supplement/4485.short |
Abstract Text | Cancer Res 2011;71(8 Suppl):Abstract nr 4485. doi:10.1158/1538-7445.AM2011-4485 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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PWT33597 | mTOR Inhibitor 51 PIK3CA inhibitor 18 | PWT33597 is a dual PIK3CA and mTOR inhibitor, which may induce apoptosis in cells with activated PI3K or mTOR pathways (Cancer Res 2011;71(8 Suppl):Abstract nr 4485). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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PIK3CA mutant | lung non-small cell carcinoma | sensitive | PWT33597 | Preclinical | Actionable | In a preclinical study, PWT33597 decreased signaling of mTOR and PIK3 pathways in non-small cell lung cancer cells with Pik3ca mutations (Cancer Res 2011;71(8 Suppl):Abstract nr 4485). | detail... |
PIK3CA mutant | colon cancer | sensitive | PWT33597 | Preclinical | Actionable | In a preclinical study, PWT33597 decreased signaling of mTOR and PIK3 pathways in colon cancer cells with Pik3ca mutations (Cancer Res 2011;71(8 Suppl):Abstract nr 4485). | detail... |