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Ref Type
PMID
Authors Nanxin Li, Daniel J. Poon, Kimberly Aardalen, Susan Kaufman, Hanne Merritt, Fernando Salangsang, Edward Lorenzana, Allen Li, Majid Ghoddusi, Giordano Caponigro, Frank Sun, Swarupa Kulkarni, Shefali Kakar, Nancy Turner, Richard Zang, John Tellew, Nancy Pry
Title Abstract 3790: Preclinical profile of LGX818: A potent and selective RAF kinase inhibitor
Journal Cancer Research
Vol 72
Issue 8, Suppliment 1
Date April 15
URL http://cancerres.aacrjournals.org/cgi/content/short/72/8_MeetingAbstracts/3790
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E melanoma sensitive Encorafenib Preclinical - Cell line xenograft Actionable In preclinical studies, Encorafenib (LGX818) treatment of human melanoma xenograft models with BRAF V600E significantly decreased Mek activation and resulted in tumor regression (Cancer Res: 72(8) Suppl 1, Abstract #3790). detail...