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Ref Type
PMID
Authors Stefan D. Gross, R. Xu, M. Boys, K. Condroski, L. DeMeese, W.E. DeWolf, B. Fell, J. Fischer, S. Gloor, M. J. Humphries, G. Miknis, K. Regal, M.Rodriguez, N. Raddatz, K. Shotts, G. Topalov, E. Wallace, J. Zuzack, J. A. Josey, J. Winkler, Kevin Koch
Title Abstract 4484: AR-mTOR-26 - A potent, selective mTORC 1/2 kinase inhibitor for the treatment of malignancy
Journal Cancer Res April 15, 2010 70; 4484
Vol
Issue
Date
URL http://cancerres.aacrjournals.org/content/70/8_Supplement/4484.short
Abstract Text for oncology.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
AR-mTOR-26 AR-mTOR-26 1 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
AR-mTOR-26 AR mTOR 26 mTOR Inhibitor 51 AR-mTOR-26 is a selective inhibitor of mTOR, which leads to decreased signaling through mTORC1 and mTORC2, and may lead to decreased tumor growth (Cancer Res April 15, 2010 70; 4484, PMID: 20024839).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss prostate cancer predicted - sensitive AR-mTOR-26 Preclinical - Cell line xenograft Actionable In a preclinical study, AR-mTOR-26 treatment resulted in antitumor activity in prostate cancer xenograft models with PTEN loss (Cancer Res 2010;70(8 Suppl):Abstract nr 4484). detail...