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Ref Type
Authors C. Festuccia, G.L. Gravina, A. Mancini, N. Rucci, C. Liang, M. Capulli, C. Tatone, J. Gibbons, A.M. Teti, E.A. Jannini
Title 976 Effects of Dual PI3K and mTOR Inhibition on Incidence and Local Growth of Prostate Cancer Bone Metastases
Journal European Journal of Cancer
Vol 48, Supp 5
Date July 2012
Abstract Text doi:10.1016/S0959-8049(12)71594-0


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
X480 X480 1 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
X480 mTOR Inhibitor 51 PI3K Inhibitor (Pan) 37 X480 is a dual PI3K/mTOR inhibitor, which may lead to decreased tumor growth and metastasis (Eur J Cancer, 2012, 48, S5:235, PMID: 29687745).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown prostate cancer not applicable X480 Preclinical - Cell line xenograft Actionable In a preclinical study, treatment with X480 in prostate cancer cell lines resulted in reduced cell proliferation and induced apoptotic activity in culture, and decreased tumor load and metastasis in cell line xenograft models (Eur J Cancer, 2012, 48, S5:235). detail...