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Authors | C. Festuccia, G.L. Gravina, A. Mancini, N. Rucci, C. Liang, M. Capulli, C. Tatone, J. Gibbons, A.M. Teti, E.A. Jannini | ||||||||||||
Title | 976 Effects of Dual PI3K and mTOR Inhibition on Incidence and Local Growth of Prostate Cancer Bone Metastases | ||||||||||||
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URL | http://www.sciencedirect.com/science/article/pii/S0959804912715940 | ||||||||||||
Abstract Text | doi:10.1016/S0959-8049(12)71594-0 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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X480 | mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40 | X480 is a dual PI3K/mTOR inhibitor, which may lead to decreased tumor growth and metastasis (Eur J Cancer, 2012, 48, S5:235, PMID: 29687745). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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