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Ref Type
Authors J.S. de Bono, U. De Giorgi, C. Massard, S. Bracarda, D. Nava Rodrigues, I.Kocak, A. Font, J. Arranz Arija, K. Shih, G.D. Radavoi, W. Yu, W. Chan, S. Gendreau, L. Zhang, R. Riisnaes, M.J. Wongchenko, D. Maslyar, V. Jinga
Title PTEN loss as a predictive biomarker for the Akt inhibitor ipatasertib combined with abiraterone acetate in patients with metastatic castration-resistant prostate cancer (mCRPC)
Journal Annals of Oncology
Abstract Text Ann Oncol (2016) 27 (suppl_6): 718O


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss castration-resistant prostate carcinoma sensitive Abiraterone + Ipatasertib Phase II Actionable In a Phase II trial, the combination of Ipatasertib (GDC-0068) and Zytiga (abiraterone) resulted in a better progression-free survival in metastatic castration resistant prostate cancer patients with PTEN loss (by IHC) when compared to placebo combined with Zytiga (PMID: 30037818; NCT01485861). 30037818 detail...