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ID DOID:80909
Name castration-resistant prostate carcinoma
Definition A prostate carcinoma that is characterized by continued growth and spread despite the surgical removal of the testes or medical intervention to block androgen production.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer reproductive organ cancer male reproductive organ cancer prostate cancer prostate carcinoma castration-resistant prostate carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
PTEN loss Abiraterone + Ipatasertib castration-resistant prostate carcinoma sensitive detail...
PTEN loss Enzalutamide + GSK2636771 castration-resistant prostate carcinoma no benefit detail...
PTEN inact mut CC-115 + Enzalutamide castration-resistant prostate carcinoma predicted - sensitive detail...
PIK3CA act mut CC-115 + Enzalutamide castration-resistant prostate carcinoma predicted - sensitive detail...
TSC1 loss CC-115 + Enzalutamide castration-resistant prostate carcinoma predicted - sensitive detail...
TSC2 loss CC-115 + Enzalutamide castration-resistant prostate carcinoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03903835 Phase III Docetaxel Cabazitaxel Carboplatin Abiraterone Enzalutamide ProBio: A Biomarker Driven Study in Patients With Metastatic Castrate Resistant Prostate Cancer (ProBio) Recruiting 2
NCT04926181 Phase II Apalutamide + JNJ-63723283 Apalutamide Plus Cetrelimab in Patients With Treatment-Emergent Small Cell Neuroendocrine Prostate Cancer Not yet recruiting USA 0
NCT04946370 Phase Ib/II Pembrolizumab 225Ac-J591 + Pembrolizumab Maximizing Responses to Anti-PD1 Immunotherapy With PSMA-targeted Alpha Therapy in mCRPC Recruiting USA 0
NCT05005728 Phase II XmAb20717 Olaparib + XmAb20717 Cabazitaxel + Carboplatin + XmAb20717 XmAb20717 Alone or in Combination With Chemotherapy or Targeted Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer Recruiting USA 0