Disease Detail


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ID DOID:80909
Name castration-resistant prostate carcinoma
Definition A prostate carcinoma that is characterized by continued growth and spread despite the surgical removal of the testes or medical intervention to block androgen production.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer reproductive organ cancer male reproductive organ cancer prostate cancer prostate carcinoma castration-resistant prostate carcinoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
PTEN loss Abiraterone + Ipatasertib castration-resistant prostate carcinoma sensitive detail...
PTEN loss Enzalutamide + GSK2636771 castration-resistant prostate carcinoma no benefit detail...
PTEN inact mut CC-115 + Enzalutamide castration-resistant prostate carcinoma predicted - sensitive detail...
PIK3CA act mut CC-115 + Enzalutamide castration-resistant prostate carcinoma predicted - sensitive detail...
PTEN N323fs Everolimus castration-resistant prostate carcinoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03436485 Phase Ib/II ODM-208 Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate Cancer (CYPIDES) Recruiting USA | FRA 2
NCT03903835 Phase III Docetaxel Cabazitaxel Carboplatin Abiraterone Enzalutamide ProBio: A Biomarker Driven Study in Patients With Metastatic Castrate Resistant Prostate Cancer (ProBio) Recruiting BEL 3
NCT04434482 Phase I Senaparib + Temozolomide IMP4297 in Combination With Temozolomide in Patients With Advanced Solid Tumors and Small Cell Lung Cancer Recruiting 3
NCT04839991 Phase I CB307 Study of CB307 in Patients With Advanced and/or Metastatic PSMA-positive Tumours. (POTENTIA) Recruiting ESP 2
NCT04926181 Phase II Apalutamide + Cetrelimab Apalutamide Plus Cetrelimab in Patients With Treatment-Emergent Small Cell Neuroendocrine Prostate Cancer Recruiting USA 0
NCT04946370 Phase Ib/II Pembrolizumab 225Ac-J591 + Pembrolizumab Maximizing Responses to Anti-PD1 Immunotherapy With PSMA-targeted Alpha Therapy in mCRPC Recruiting USA 0
NCT05005728 Phase II XmAb20717 Olaparib + XmAb20717 Cabazitaxel + Carboplatin + XmAb20717 XmAb20717 Alone or in Combination With Chemotherapy or Targeted Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer Recruiting USA 0
NCT05057013 Phase Ib/II HMBD-001 HMBD-001 in Advanced HER3 Positive Solid Tumours Recruiting 1
NCT05107674 Phase I NX-1607 A Study of NX-1607 in Adults With Advanced Malignancies Recruiting 1
NCT05256381 Phase II Pembrolizumab + SOT101 A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors Recruiting USA | ITA | FRA | ESP | BEL 2
NCT05369000 Phase Ib/II LAVA-1207 Trial of LAVA-1207 in Patients With Therapy Refractory Metastatic Castration Resistant Prostate Cancer Recruiting USA 0
NCT05501548 Phase II Olaparib Phase II Study of PARP Inhibitor Olaparib and IV Ascorbate in Castration Resistant Prostate Cancer Not yet recruiting USA 0
NCT05534646 Phase II Apalutamide Apalutamide + Carotuximab Study of Apalutamide With Carotuximab in Metastatic, Castration-Resistant Prostate Cancer Not yet recruiting USA 0
NCT05592626 Phase Ib/II STAR0602 A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors (START-001) Recruiting USA 0