Therapy Detail
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| Therapy Name | Brequinar |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Brequinar | DUP 785|DUP785|DUP-785|NSC368390|NSC-368390|NSC 368390|Bipenquinate | Brequinar (DUP 785) is a small molecule that selectively inhibits the activity of Dihydroorotate dehydrogenase (DHODH), potentially resulting in increased myeloid differentiation and decreased tumor burden (PMID: 27641501, PMID: 32525770). |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
- Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| Unknown unknown | acute myeloid leukemia | not applicable | Brequinar | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, Brequinar treatment induced differentiation of acute myeloid leukemia cell lines in culture, reduced colony formation of tumor cells, decreased leukemic burden and leukemia initiating cells, and increased survival in syngeneic mouse models, induced differentiation of tumor cells, reduced tumor growth, and increased survival in cell line xenograft models, and induced differentiation of tumor cells and reduced leukemic burden in a patient-derived xenograft (PDX) model (PMID: 27641501). | 27641501 |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
- Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|---|---|---|---|
| NCT03760666 | Phase Ib/II | Brequinar | A Study of Brequinar in Subjects With Relapsed/Refractory Acute Myeloid Leukemia | Recruiting |
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