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DS-3078a is a small molecule that inhibits mTOR kinase activity and downstream signaling, resulting in decreased tumor cell growth (Mol Cancer Ther 2013;12(11 Suppl):B184).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|DS-3078a||mTOR Inhibitor 51||DS-3078a is a small molecule that inhibits mTOR kinase activity and downstream signaling, resulting in decreased tumor cell growth (Mol Cancer Ther 2013;12(11 Suppl):B184).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||DS-3078a||Phase I||Actionable||In a Phase I trial, DS-3078a demonstrated safety and preliminary efficacy in patients with advanced solid tumors (Mol Cancer Ther November 2013 12:C173).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT01588678||Phase I||DS-3078a||A Open-Label, Multiple Ascending Dose Study of DS-3078a, an Oral TORC1/2 Kinase Inhibitor, in Subjects With Advanced Solid Tumors or Lymphomas||Completed||USA||0|