Therapy Detail

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Therapy Name TAS0612
Synonyms
Therapy Description

TAS0612 is a multikinase inhibitor that blocks the activity of Akt, p70S6K, and p90RSK, and decreases phosphorylation of Ybx1, potentially resulting in reduced tumor cell proliferation and inhibition of tumor growth (PMID: 31879363).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TAS0612 TAS-0612|TAS 0612 Akt Inhibitor (Pan) 21 TAS0612 is a multikinase inhibitor that blocks the activity of Akt, p70S6K, and p90RSK, and decreases phosphorylation of Ybx1, potentially resulting in reduced tumor cell proliferation and inhibition of tumor growth (PMID: 31879363).

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN R142fs PTEN L265fs ovarian cancer sensitive TAS0612 Preclinical - Cell line xenograft Actionable In a preclinical study, TAS0612 inhibited proliferation in a clear cell ovarian cancer cell line harboring PTEN R142fs and L265fs, along with KRAS G13C and PIK3CA H1047Y, in culture and induced tumor regression in a cell line xenograft model (PMID: 37906695). 37906695
PTEN K6fs endometrial cancer sensitive TAS0612 Preclinical - Cell line xenograft Actionable In a preclinical study, TAS0612 inhibited proliferation in an endometrial cancer cell line harboring PTEN K6fs along with PIK3CA mutations in culture and induced tumor regression in a cell line xenograft model (PMID: 37906695). 37906695
PTEN L320* endometrial cancer sensitive TAS0612 Preclinical - Cell line xenograft Actionable In a preclinical study, TAS0612 inhibited proliferation in an endometrial cancer cell line harboring PTEN L320* along with ERBB2 (HER2) R896H and FGFR2 S252W in culture and induced tumor regression in a cell line xenograft model (PMID: 37906695). 37906695
PTEN P89fs breast cancer sensitive TAS0612 Preclinical - Cell line xenograft Actionable In a preclinical study, TAS0612 inhibited proliferation in a breast cancer cell line harboring PTEN P89fs in culture and induced tumor regression in a cell line xenograft model (PMID: 37906695). 37906695

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04586270 Phase I TAS0612 A Study of TAS0612 in Participants With Advanced or Metastatic Solid Tumor Cancer Recruiting USA | FRA 0


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