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Therapy Name | A-485 + JQ1 |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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A-485 | A385 | CBP/p300 inhibitor 13 | A-485 is a selective histone acetyltransferase inhibitor of EP300 and CREBBP, which induces cellular senescence, and may result in decreased cell proliferation and inhibition of tumor growth (PMID: 28953875, PMID: 30266801, PMID: 32366905). | |
JQ1 | JQ-1 | BET Inhibitor (Pan) 32 | JQ1 is a BET bromodomain inhibitor with greatest specificity towards BRD4, resulting in decreased Myc expression, increased cell death, reduced macrophage immunosuppression, and inhibition of tumor growth (PMID: 24231268, PMID: 31018997, PMID: 30906568, PMID: 32800944). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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