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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|E7777||E-7777|E 7777||E777 is a recombinant protein consisting of the binding domain of the cytokine IL-2 fused to fragments A and B of the diphtheria toxin, which binds to the IL-2 receptor on tumor cells, and following endocytosis leads to inhibition of protein synthesis, potentially resulting in cell death (PMID: 33792128, NCI Thesaurus).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT01871727||Phase III||E7777||A Trial of E7777 in Persistent and Recurrent Cutaneous T-Cell Lymphoma||Completed||USA||2|
|NCT04855253||Phase Ib/II||E7777||Study of E7777 Prior to Kymriah for R/R DLBCL||Recruiting||USA||0|