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|Therapy Name||B7-H3 CAR T cells + Cyclophosphamide + Fludarabine + Mesna|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|B7-H3 CAR T cells||SCRI-CARB7H3(s)||B7-H3 CAR T cells are T-cells engineered to express a chimeric antigen receptor (CAR) that targets B7-H3, which potentially decrease growth of B7-H3-expressing tumor cells (PMID: 31485480).|
|Cyclophosphamide||Cytoxan||CPM||Chemotherapy - Alkylating 16||Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).|
|Fludarabine||Fludara||FAMP|Fludarabine phosphate||Flurdara (fludarabine) is converted to 2-fluoro-ara-ATP intracellularly, which potentially inhibits DNA polymerase alpha, ribonucleotide reductase and DNA primase, leading to decreased DNA synthesis and reduced tumor growth (NCI Drug Dictionary)|
|Mesna||Mesnex||D-7093|UCB 398|MSA|mercaptoethane sulfonate|Mesnum|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04897321||Phase I||B7-H3 CAR T cells + Cyclophosphamide + Fludarabine + Mesna||B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)||Recruiting||USA||0|