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|Therapy Name||Lenalidomide + VAY736|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Lenalidomide||Revlimid||IMiD-1||Revlimid (lenalidomide) is a thalidomide analog which regulates cytokine production and stimulates T cells and NK cells activity (PMID: 24328678). Revlimid (lenalidomide) is FDA approved for use in multiple myeloma, relapsed or refractory Mantle cell lymphoma, and in combination with a rituximab product in follicular lymphoma and marginal zone lymphoma (FDA.gov).|
|VAY736||VAY 736|VAY-736|Ianalumab||VAY736 (Ianalumab) is a monoclonal antibody against the receptor for B cell activating Factor of the TNF family (BAFF-R), which may inhibit B cell differential and survival (Annals of the Rheumatic Diseases 75(Suppl 2): THU0313, PMID: 31138521).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04903197||Phase I||Lenalidomide + VAY736 VAY736||Study of VAY736 as Single Agent and in Combination With Select Antineoplastic Agents in Patients With Non-Hodgkin Lymphoma||Recruiting||USA | ITA | ESP | DEU||4|