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Therapy Name | P-MUC1C-ALLO1 CAR-T cells + Rimiducid |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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P-MUC1C-ALLO1 CAR-T cells | P-MUC1C-ALLO1 CAR-T are allogeneic T-cells engineered to target MUC1C, with potential antitumor activity (Journal for ImmunoTherapy of Cancer 2020;8, Issue Suppl 3). | |||
Rimiducid | AP1903|AP-1903|AP 1903 | Rimiducid (AP1903) is a small molecule that selectively binds to mutant FKBP12 and induces dimerization and downstream signaling, which can be used to activate a safety switch in transplanted cells to potentially induce apoptosis and prevent graft-versus-host disease (PMID: 9724721, PMID: 22047558, PMID: 28697888). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT05239143 | Phase I | P-MUC1C-ALLO1 CAR-T cells + Rimiducid | P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors | Recruiting | USA | 0 |