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Drug Name Rimiducid
Trade Name
Synonyms AP1903|AP-1903|AP 1903
Drug Descriptions

Rimiducid (AP1903) is a small molecule that selectively binds to mutant FKBP12 and induces dimerization and downstream signaling, which can be used to activate a safety switch in transplanted cells to potentially induce apoptosis and prevent graft-versus-host disease (PMID: 9724721, PMID: 22047558, PMID: 28697888).

CAS Registry Number 195514-63-7
NCIT ID C82412


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Therapy Name Drugs Efficacy Evidence Clinical Trials
BPX-601 + Rimiducid BPX-601 Rimiducid 0 1
BPX-701 + Rimiducid BPX-701 Rimiducid 0 0
Cyclophosphamide + Fludarabine + Rimiducid + TROP2-CAR/IL15-transduced CBNK cells Cyclophosphamide Fludarabine Rimiducid TROP2-CAR/IL15-transduced CBNK cells 0 0
P-BCMA-101 CAR-T cells + Rimiducid P-BCMA-101 CAR-T cells Rimiducid 0 0
P-BCMA-ALLO1 + Rimiducid P-BCMA-ALLO1 Rimiducid 0 1
P-MUC1C-ALLO1 CAR-T cells + Rimiducid P-MUC1C-ALLO1 CAR-T cells Rimiducid 0 1
P-PSMA-101 CAR-T cells + Rimiducid P-PSMA-101 CAR-T cells Rimiducid 0 0
Rimiducid Rimiducid 0 13
Rimiducid + Rivogenlecleucel Rimiducid Rivogenlecleucel 0 2

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