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Therapy Name DNIB0600A
Synonyms
Therapy Description

DNIB0600A (lifastuzumab vedotin) is an antibody-drug conjugate targeting SLC34A2 and is conjugated to monomethyl auristatin E, which leads to disruption of the microtubule network in SLC34A2-expressing cancer cells, thereby potentially inhibiting cell proliferation (PMID: 29401246).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DNIB0600A Lifastuzumab vedotin DNIB0600A (lifastuzumab vedotin) is an antibody-drug conjugate targeting SLC34A2 and is conjugated to monomethyl auristatin E, which leads to disruption of the microtubule network in SLC34A2-expressing cancer cells, thereby potentially inhibiting cell proliferation (PMID: 29401246).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown lung non-small cell carcinoma not applicable DNIB0600A Phase I Actionable In a Phase I trial, DNIB0600A (lifastuzumab vedotin) treatment demonstrated a safe profile, but resulted in limited efficacy in patients with non-small cell lung cancer receiving a dose of 1.8-2.8 mg/kg, which included a partial response in 8% (4/51) of patients regardless of Slc34a2 expression and a partial response in 12% (3/26) of patients with over expression of Slc34a2 (PMID: 31540980; NCT01363947). 31540980
Unknown unknown ovarian cancer not applicable DNIB0600A Phase I Actionable In a Phase I trial, DNIB0600A (lifastuzumab vedotin) treatment demonstrated a safe profile and resulted in efficacy in patients with platinum-resistant ovarian cancer receiving a dose of 1.8-2.8 mg/kg, which included a partial response in 46% (11/24) of patients regardless of Slc34a2 expression and a partial response in 50% (11/22) of patients with over expression of Slc34a2 (PMID: 31540980; NCT01363947). 31540980

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT01991210 Phase II DNIB0600A Pegylated liposomal-doxorubicin A Randomized Study of DNIB0600A in Comparison With Pegylated Liposomal Doxorubicin in Patients With Platinum-Resistant Ovarian Cancer Terminated


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