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Therapy Name KIN-3248
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
KIN-3248 KIN3248|KIN 3248 FGFR Inhibitor (Pan) 23 KIN-3248 is a small molecule pan-FGFR inhibitor with activity against secondary resistance mutations, potentially inhibiting tumor growth (J Clin Oncol 40, 2022 (suppl 4; abstr 461)).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 - PHGDH cholangiocarcinoma predicted - sensitive KIN-3248 Preclinical Actionable In a preclinical study, KIN-3248 treatment was active in a cholangiocarcinoma cell line harboring FGFR2-PHGDH (J Clin Oncol 40, 2022 (suppl 4; abstr 461). detail...
FGFR2 - OPTN cholangiocarcinoma predicted - sensitive KIN-3248 Preclinical Actionable In a preclinical study, KIN-3248 treatment was active in a cholangiocarcinoma cell line harboring FGFR2-OPTN (J Clin Oncol 40, 2022 (suppl 4; abstr 461). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05242822 Phase I KIN-3248 A Study to Evaluate KIN-3248 in Participants With Advanced Tumors Harboring FGFR2 and//or FGFR3 Gene Alterations Recruiting USA 1


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