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Therapy Name JSKN003
Synonyms
Therapy Description

JSKN003 is an antibody-drug conjugate (ADC) comprising a bispecific antibody targeting two epitopes of ERBB2 (HER2) linked to a topoisomerase inhibitor, which potentially induces cell cycle arrest and apoptosis of ERBB2 (HER2)-expressing tumor cells and results in antitumor activity (J Clin Oncol 42, 2024 (suppl 16; abstr 3038), NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
JSKN003 JSKN 003|JSKN-003 HER2 (ERBB2) Antibody 75 HER2 (ERBB2) Antibody-Drug Conjugate 29 JSKN003 is an antibody-drug conjugate (ADC) comprising a bispecific antibody targeting two epitopes of ERBB2 (HER2) linked to a topoisomerase inhibitor, which potentially induces cell cycle arrest and apoptosis of ERBB2 (HER2)-expressing tumor cells and results in antitumor activity (J Clin Oncol 42, 2024 (suppl 16; abstr 3038), NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05494918 Phase I JSKN003 First-In-Human Study in Subjects With Advanced or Metastatic Solid Malignant Tumors Recruiting AUS 0


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