Therapy Detail

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Therapy Name CD38-SADA + Lutetium Lu 177-DOTA
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CD38-SADA Anti-CD38 scFv/Anti-DOTA scFv Fusion Protein CD38-SADA CD38 Antibody 20 CD38-SADA is a fusion protein comprising a single chain variable fragment targeting CD38, a single chain variable fragment targeting the chelating agent DOTA, and a self-assembling and disassembling (SADA) domain, which potentially allows selective delivery of a radioactive payload to CD38-expressing tumor cells (NCI Drug Dictionary).
Lutetium Lu 177-DOTA 177Lu-DOTA|Lu-177-DOTA Lutetium Lu 177-DOTA is a radioconjugate comprising the radionuclide Lutetium-177 linked to the chelating agent DOTA, which potentially delivers beta radiation (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05994157 Phase I CD38-SADA + Lutetium Lu 177-DOTA Phase 1, Open-label, Dose-escalation Trial With CD38-SADA:177 Lu-DOTA Drug Complex in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma Not yet recruiting USA 0


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