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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|ZM336372||ZM 336372|ZM-336372||CRAF Inhibitor 11||ZM336372 is a small molecule RAF1 inhibitor that paradoxically causes RAF1 activation through a putative feedback mechanism, resulting in decreased proliferation and cell cycle inhibition in carcinoid tumor cells (PMID: 20031160, PMID: 15956248).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF V600E||high grade glioma||no benefit||ZM336372||Preclinical - Patient cell culture||Actionable||In a preclinical study, ZM336372 treatment did not lead to inhibition of cell growth in a patient-derived glioma cell line harboring BRAF V600E in culture (PMID: 34433654).||34433654|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|