Therapy Detail

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Therapy Name Savolitinib
Synonyms
Therapy Description

Savolitinib (AZD6094) is a selective MET inhibitor, which inhibits MET kinase activity, resulting in decreased downstream signaling, and may inhibit growth of MET-expressing tumors (PMID: 25248999, PMID: 32027846, PMID: 30952639).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Savolitinib HMPL-504|AZD6094|AZD-6094|Volitinib MET Inhibitor 59 Savolitinib (AZD6094) is a selective MET inhibitor, which inhibits MET kinase activity, resulting in decreased downstream signaling, and may inhibit growth of MET-expressing tumors (PMID: 25248999, PMID: 32027846, PMID: 30952639).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03598244 Phase I Savolitinib Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors Recruiting USA | CAN 0
NCT03592641 Phase II Savolitinib Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer Terminated USA 0
NCT04606771 Phase II Savolitinib Osimertinib + Savolitinib A Study Comparing Savolitinib Plus Osimertinib vs Savolitinib Plus Placebo in Patients With EGFRm+ and MET Amplified Advanced NSCLC (CoC) Active, not recruiting USA 5
NCT03091192 Phase III Sunitinib Savolitinib Savolitinib vs. Sunitinib in MET-driven PRCC. Active, not recruiting USA | ITA | FRA 4
NCT02127710 Phase II Savolitinib A Phase II Trial to Evaluate the Efficacy of AZD6094 (HMPL-504) in Patients With Papillary Renal Cell Carcinoma (PRCC) Completed USA | GBR | ESP | CAN 0
NCT03385655 Phase II Savolitinib Darolutamide Adavosertib Prostate Cancer Biomarker Enrichment and Treatment Selection Active, not recruiting CAN 0
NCT02761057 Phase II Savolitinib Cabozantinib Crizotinib Sunitinib Cabozantinib-S-Malate, Crizotinib, Volitinib, or Sunitinib Malate in Treating Patients With Locally Advanced or Metastatic Kidney Cancer Active, not recruiting USA | CAN 0


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