Therapy Detail

Therapy Name NC043
Synonym
Therapy Description

NC043 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling resulting in apoptosis and interruption of the cell cycle (PMID: 21321609).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NC043 CTNNB1 Inhibitor 26 NC043 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling resulting in apoptosis and interruption of the cell cycle (PMID: 21321609).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC inact mut colorectal cancer sensitive NC043 Preclinical - Cell line xenograft Actionable In a preclinical study, NC043 inhibited Wnt pathway activation and growth of colorectal cancer cell lines harboring APC truncation mutations in culture and in cell line xenograft models (PMID: 21321609). 21321609
Clinical Trial Phase Therapies Title Recruitment Status