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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|JW55||JW 55||Tankyrase Inhibitor 10||JW55 selectively inhibits Wnt/beta-catenin-mediated signaling by inhibiting tankyrase1/2, thus stabilizing axin and stimulating beta-catenin degradation, which prevents cell division and decreases tumor growth (PMID: 22440753).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|APC inact mut||colon cancer||sensitive||JW55||Preclinical||Actionable||In a preclinical study, JW55 inhibited proliferation of colorectal cancer cells with an APC truncation mutation in culture and decreased tumor development in a mouse model expressing a conditional APC truncation mutation (PMID: 22440753).||22440753|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|