Therapy Detail

Therapy Name iCRT-14
Synonym
Therapy Description

iCRT-14 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling and results in inhibition of cell proliferation (PMID: 24188694).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
iCRT-14 CTNNB1 Inhibitor 26 iCRT-14 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling and results in inhibition of cell proliferation (PMID: 24188694).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC inact mut colon cancer sensitive iCRT-14 Preclinical - Cell line xenograft Actionable In a preclinical study, iCRT-14 induced cell-cycle arrest and inhibited proliferation of colon cancer cells harboring APC inactivating mutations in culture and decreased initial tumor growth in APC-mutant colon cancer cell line xenograft models (PMID: 21393571). 21393571
Clinical Trial Phase Therapies Title Recruitment Status